Take US 129 (South) to Maryville, TN, then US 321 (North) (which joins TN 73) through Townsend, TN. Shortly after the Townsend Visitor Center take the road to The Great Smoky Mountains National Park.
Shortly after entering the Park you'll come to a "Y." You have two choices:
If it's before noon, take the "Y." to the right and at the stop sign turn right and go along Laurel creek Road to Cades Cove. Cades Cove, a large cove, was acquired from the Cherokee by the State of Tennesse, sold to speculators who in turn sold land to settlers who started arriving in 1820. At its peak, Cades Cove was home to 137 households and 685 persons. Many of the settlement's buildings remain. After completing the Cades Cove loop return in the direction you came and continue straight passing the "Y" (You are now on Little River Road, one of America's most beautiful.). Continue until you can turn left into The Sugarlands Visitor Center, a pleasant stop to view the displays of mounted wildlife and preserved wildflowers. Exiting the Visitor center turn left on Little River Road and in a few hundred yards turn right at the Stop sign onto US 441 (South).
If it's after noon, take the "Y." to the left and at the stop sign turn left onto Little River Road (one of America's most beautiful), continue until you can turn left into The Sugarlands Visitor Center, a pleasant stop to view the displays of mounted wildlife and preserved wildflowers. Exiting the Visitor center turn left on Little River Road and in a few hundred yards turn right at the Stop sign onto US 441 (South).
Continue on US 441 (South) watching your odometer. After 4.6 miles turn into The Chimneys Picnic Area: even if you aren't going to have a picnic it's worth while to drive through and look at the West Prong of the Little Pigeon River which runs along side the picnic area. Shortly after entering the picnic area on the right is the start of a mile long self-guided tour (written guide available at the trail head) thru one of the very few stands of mature cove hardwoods left in the US.
Continuing on US 441 (South) for another 8.6 miles (13.2 miles after Sugarlands Visitor Center) is Newfound Gap (where FDR dedicated The Great Smoky Mountain National Park in 1940) which offers spectacular vistas in opposing directions and an opportunity to say: "I hiked The Appalachian Trail" (The Appalachian Trail is at the NE corner of the parking lot, and there is a sign there so you can get photographic proof of your claim!).
Continue on for 0.2 miles turning right to take a 20 minute driving detour and a 15 minute cardiovascular exercise for a 360 view from the top of the Observation Tower on the top of Clingman's Dome, the highest peak in the Smokies ( http://www.mountainparadisefound.com/Scenicclingmans.html ).
Return to US 441 South turn right and start your descent to Cherokee. There are numerous overlooks - some with quiet walkways that don't go anywhere in particular, they just let you enjoy the beauty - along the way.
Near the bottom of the mountain (28.7 miles from where you started) turn right into the parking lot for Mingus Mill. The mill still works, and the historical society grinds corn from early Spring through Fall. If you miss them it is still worth a visit not only for the mill, but for a pleasant walk along the stream.
Returning to US 441 South, it's only a half mile to the Oconaluftee Visitor Center, an important stop mostly because adjacent to the Visitor Center is the Mountain Farm Museum, a self-guided open-air museum of original pioneer farm buildings.
Leave the park an contiue through Cherokee, when US 441 seems to dead-end at a stoplight in front of a stone church with a KFC on your right, turn right. At the next stoplight turn left: you are still on US 441 (South).
When US 441 joins US 74 continue on US 74 (East) / 441 (South) towards Sylva & Dillsboro for 4.5 miles, and you will see a Super Track Gas Station and an Exxon on your left and a new bridge and an old steel girder bridge on your right. Turn right and go across the new bridge (Barkers Creek Road).
After 0.2 miles on Barkers Creek, take the "Y" to the right (Thomas Valley Road).
Go 1.1 miles on Thomas Valley Road, turn left on Nations Creek Road.
Go 0.3 miles on Nations Creek Road (You cannot see the Inn from Nations Creek Road) and turn right onto Lone Oak Drive passing in front of a miniature Chalet. After going 200 feet and crossing over the creek, take the paved right fork 300 yards up the mountain to The Chalet Inn.